Phenylpropanolamine: Frequently Asked Questions

What is phenylpropanolamine (PPA)?

Phenylpropanolamine (PPA), or phenylpropanolamine hydrochloride, is an ingredient that was used in many over-the-counter cold medications as a decongestant, and in over-the-counter diet drugs as an appetite suppressant.

What side effects does PPA cause?

Use of over-the-counter cold medications and weight loss drugs containing phenylpropanolamine (PPA) has been linked to hemorrhagic stroke.

What is a hemorrhagic stroke?

A hemorrhagic stroke occurs when an artery in the brain ruptures and the leaking blood puts pressure on brain tissue, causing damage to the surrounding area. In addition, brain cells beyond the rupture will be deprived of oxygen-rich blood and may become damaged.

Why did the FDA recall phenylpropanolamine?

The FDA recalled phenylpropanolamine (PPA) because of research conducted by scientists at Yale University School of Medicine. The researchers discovered that PPA is linked to an increased risk of hemorrhagic stroke in women.

What kinds of drugs contain PPA?

Cold medications such as Dimetapp, Robitussin, Comtrex, Triaminic, Contac, and Alka Seltzer Plus contain PPA. In addition, diet pills such as Acutrim and Dexatrim contain phenylpropanolamine. Check with a pharmacist if you are unsure whether a medication you are taking contains PPA.